Among currently available technologies, spray drying, roller compaction, high shear mixing, and fluid bed granulation are worth of note. The type of process selection requires thorough knowledge of physicochemical properties of the drug, excipients, required flow and release properties, to name a few. Granulation process can be divided into two types: wet granulation that utilize a liquid in the process and dry granulation that requires no liquid. together with physical and chemical stability of the drug. Nevertheless, granulation poses numerous challenges due to high quality requirement of the formed granules in terms of content uniformity and physicochemical properties such as granule size, bulk density, porosity, hardness, moisture, compressibility, etc. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy to compress. Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules.
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